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Selected Publications - Kemkemer (since 2006)

  
  You may find an up-to-date list at ResearchGate or Google Scholar (also with publications before 2006) 

 

  1. V. Häussling, S. Deninger, L. Vidoni, H. Rinderknecht, M. Ruoß, C. Arnscheidt, K. Athanasopulu, R. Kemkemer, A.K. Nussler, S. Ehnert. Impact of Four Protein Additives in Cryogels on Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells. Bioengineering 20196(3), 67; https://doi.org/10.3390/bioengineering6030067
  2. L. Yang, Z. Zhang, K. Athanasopulu, K. Frey1, Z. Cui, H. Su, L. Luo, R. Kemkemer. Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications. Current Directions in Biomedical Engineering, (2019)  5/1, 93–96, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2019-0024.
  3. S. Grützmacher, R. Kemkemer. C. Curio. Using Deep Correlation Features to define the Meta Style of Cell Images for Classification. Current Directions in Biomedical Engineering, (2019) 5/1, 227–230, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2019-0058.
  4. K. Athanasopulu, L. Kutuzova, J. Thiel, G. Lorenz and R. Kemkemer. Enhancing the biocompatibility of siliconepolycarbonate urethane based implant materialsCurrent Directions in Biomedical Engineering, (2019) 5/1, 453–455, ISSN (Online) 2364-5504, DOI: https://doi.org/10.1515/cdbme-2019-0114.
  5. Holle, A. W., & Kemkemer, R. (2019). Stronger than they look. Nature Physics, e-pup: e-pup, pp. 1-2. doi:10.1038/s41567-019-0492-x
  6. Andrew Holle, Neethu Govindan Kutty Devi, Kim Clar, Anthony Fan, M Taher Saif, Ralf Kemkemer, Joachim P Spatz. Cancer Cells Invade Confined Microchannels via a Self-Directed Mesenchymal-to-Amoeboid Transition. Nano Lett., 2019, 19 (4), pp 2280–2290, DOI: 10.1021/acs.nanolett.8b04720 
  7. A Sales, K Ende, J Diemer, AR Kyvik, J Veciana, I Ratera, R Kemkemer, JP Spatz, J Guasch. Cell Type-Dependent Integrin Distribution in Adhesion and Migration Responses on Protein-Coated Microgrooved Substrates. ACS Omega 4 (1), 1791-1800
  8. Sales, A.; Picart, C.; Kemkemer, R.: Age-dependent migratory behavior of human endothelial cells revealed by substrate microtopography. Experimental Cell Research (2018) https://doi.org/10.1016/j.yexcr.2018.10.008
  9. K. Frey, A. Fischer, R. Krastev, R. Kemkemer. CurvChip - Chip Platform for Investigating Cell Responses to Curved Surface Features. Current Directions in Biomedical Engineering, 4, 453–456, (2018), DOI: https://doi.org/10.1515/cdbme-2018-0108.
  10. S. Grützmacher, R. Kemkemer, C. Thies, C. Curio. Detecting Lamellipodia in Epithelial Cell Clusters Using a Fully Convolutional Neural Network for Phase Contrast Microscopy Images.Current Directions in Biomedical Engineering, 4, 449–452, (2018), DOI: https://doi.org/10.1515/cdbme-2018-0107.
  11. K. Mellert, S. Lechner, M. Lüdeke, M. Lamla, P. Möller, R. Kemkemer, K. Scheffzek & D. Kaufmann.Restoring functional neurofibromin by protein transduction. Scientific Reports 8: 6171 (2018) doi:10.1038/s41598-018-24310-5
  12. L. Kutuzova, K. Athanasopulu, M. Schneider, A. Kandelbauer, R. Kemkemer and G. Lorenz. In vitro bio-stability screening of novel implantable polyurethane elastomers.Current Directions in Biomedical Engineering, 4, 535–538, (2018), DOI: https://doi.org/10.1515/cdbme-2018-0128.
  13. Tendulkar, V.Sreekumar, F. Rupp, A. K. Teotia, K.Athanasopulu, R. Kemkemer, A. Buck Jr., A. Buck Sr., H. P. Kaps, Geis-Gerstorfer, A. Kumar, A. K. Nussler; Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus, Scientific Reports 7: 16611·2017 , doi:10.1038/s41598-017
  14. Huntsman HD, Rendeiro C, Merritt JR, Pincu Y, Cobert A, De Lisio M, Kolyvas E, Dvoretskiy S, Dobrucki IT, Kemkemer R, Jensen T, Dobrucki LW, Rhodes JS, Boppart MD. The impact of mechanically stimulated muscle-derived stromal cells on aged skeletal muscle. Experimental Gerontology, 103:35-46, 2017 - DOI 10.1016/j.exger.2017.12.012
  15. Sales A.R., Holle A. , Kemkemer R.. Initial contact guidance during cell spreading is contractility-independent.  Soft Matter, 2017 DOI: 10.1039/C6SM02685K
  16. Holle A., Kalafat M., Sales S.R. Seufferlein T. Kemkemer R., Spatz J.P.. Intermediate filament reorganization dynamically influences cancer cell alignment and migration. Scientific Reports 7:45152 · 2017
  17. Biela S, Striegl B, Frey K, Spatz JP, Kemkemer R. Distance-dependent adhesion of vascular cells on biofunctionalized nanostructures. Current Directions in Biomedical Engineering. 683-686, 2017
  18. Greiner, A. M., Sales, A., Chen, H., & Biela, S. A., Kaufmann D. and Kemkemer R. (2016). Nano-and microstructured materials for in vitro studies of the physiology of vascular cells. Beilstein Journal of Nanaotechnology, 7, 1620–1641. http://doi.org/10.3762/bjnano.7.155
  19. Thies C, Khachaturyan G, Zemel A, Kemkemer R. Image analysis of self-organized multicellular patterns, in: Current Directions in Biomedical Engineering 2016, 2(1), pp. 523–5277. DOI: dx.doi.org10.1515/cdbme-2016-0116

  20. Holle A., Kast V. , Kemkemer R., Spatz JP.. Cancer cell invasion dynamics in microchannels during stromal cell coculture. Cancer Research 76 (14 Supplement):5059-5059 · 2016
    DOI: 10.1158/1538-7445.AM2016-5059

  21. Kemkemer, A. Holle, G. Khachaturyan, J. P. Spatz. Tumorzellen on the Move - Mikrosystem-basierter Assay zur Untersuchung der Tumorzellen-Migration. horizonte 48/ September 2016
  22. Gittel, R. Kemkemer, R. Krastev, K. Athanasopulu, A. Rudt. Modification of polyelectrolyte multilayer coatings using nanoparticles to optimize adhesion and proliferation of different cell types. BIONANO-MATERIALS. Journal of Functional Materials, Biomechanics, and Tissue Engineering 2016 · VOLUME 17 · ISSUE S1 ISSN 2193-0651 · e-ISSN 2193-066X
  23. Athanasopulu, R. Kemkemer, G. Lorenz, L. Kutuzova. Functionalization of PU-based materials for orthopedic applications. BIONANO-MATERIALS. Journal of Functional Materials, Biomechanics, and Tissue Engineering 2016 · VOLUME 17 · ISSUE S1 ISSN 2193-0651 · e-ISSN 2193-066X
  24. Greiner A.M., S.A. Biela, H. Chen, J.P. Spatz, R. Kemkemer. Temporal responses of human endothelial and smooth muscle cells exposed to uniaxial cyclic tensile strain. Experimental Biology and Medicine, 240, DOI: 10.1177/1535370215570191 (2015)
  25. Tönjes, S. Barbus, Y.-J. Park, W. Wang, M. Schlotter, A. Lindroth, S. Pleier, H.C. Bai, D. Karra, J. Felsberg, D. Lemke, V. Hovestadt, C. Rolli, R. Kemkemer, K. Schmidt, W. Hull, S.M. Hutson, S. Pfister, C. Plass, J.G. Okun, G. Reifenberger, P. Lichter, B. Radlwimmer. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
    Nature Medicine 2013 Jul;19(7):901-8. doi: 10.1038/nm.3217. Epub 2013 Jun 23.
  26. Carisey, A. M. Greiner, R. Tsang, N. Nijenhuis, N. Heath, A. Nazgiewicz, R. Kemkemer, B. Derby, J. Spatz, C. Ballestrem. Vinculin governs a network of focal adhesion proteins in a force dependent manner.
    Current Biology 2013 Feb 18;23(4):271-81. doi: 10.1016/j.cub.2013.01.009. Epub 2013 Jan 31.
  27. Greiner AM, Chen H, Spatz JP, Kemkemer R. Cyclic Tensile Strain Controls Cell Shape and Directs Actin Stress Fiber Formation and Focal Adhesion Alignment in Spreading Cells. PLoS ONE 8(10): e77328. doi: 10.1371/journal.pone.0077328 (2013)
  28. Greiner, Alexandra M.; Hoffmann, Peter; Bruellhoff, Kristina; Jungbauer, Simon; Spatz, Joachim P.; Moeller, Martin; Kemkemer, Ralf; Groll, Juergen: Stable Biochemically Micro-patterned Hydrogel Layers Control Specific Cell Adhesion and Allow Long Term Cyclic Tensile Strain Experiments.
    Macromol. Bioscience (2014), 14(11), 1547-1555
  29. Sales, F. Wang, H. Chen, R. Kemkemer, A.M. Greiner: Cell-age and cell type-dependent behavior of human vascular cells on micro-structured or soft polymer substrates. Biomed Tech (2014); 59 (s1) (2014). DOI 10.1515/bmt-2014-4125; 270-273
  30. Frey, A. Sales, K. Athanasopulu, J. P. Spatz, R. Kemkemer: Hydrogels with precisely nano-functionalized micro-topography for cell guidance.
    Biomed Tech (2014); 59 (s1) (2014) DOI 10.1515/bmt-2014-400; 6-9
  31. Nisenholz, Noam; Rajendran, Kavitha; Dang, Quynh; Chen, Hao; Kemkemer, Ralf; Krishnan, Ramaswamy; Zemel, Assaf: Active mechanics and dynamics of cell spreading on elastic substrates.
    Soft Matter (2014), 10(37), 7234-7246
  32. Mills, K. L.; Kemkemer Ralf; Rudraraju, Shiva; Garikipati, Krishna: Elastic free energy drives the shape of prevascular solid tumors.
    PLoS One (2014), 9(7), e103245/1-e103245/7, 7 pp..
  33. B. Chen, R. Kemkemer, M. Deibler, J. Spatz, H. Gao.
    Cyclic stretch induces cell reorientation by destabilizing catch bonds in focal adhesions.
    PLoS ONE 7(11): e48346. doi:10.1371/journal.pone.0048346 (2012)
  34. Huck, R. Kemkemer, M. Franz-Wachtel, B. Macek, A. Hausser, and M.A. Olayioye. GIT1 phosphorylation on serine 46 by PKD3 regulates paxillin trafficking and cellular protrusive activity.
    Journal of Biological Chemistry, 2012; DOI:10.1074/jbc.M112.374652
  35. Kaufmann, D., Hoesch, J., Su, Y., Deeg, L., Mellert, K., Spatz, J.P., Kemkemer, R.:
    Partial Blindness to Submicron Topography in NF1 Haploinsufficient Cultured Fibroblasts Indicates a New Function of Neurofibromin in Regulation of Mechanosensoric.
    Mol Syndromol 2012, DOI:10.1159/000342698
  36. G. Rolli, H. Nakayama, K. Yamaguchi, J.P. Spatz, J. Nakanishi* and R. Kemkemer* (*contributed equally). Switchable adhesive substrates: Revealing geometry dependence in collective cell behavior.
    Biomaterials. 33, 2409-18, (2012)
  37. Bai, T. Milde, M. Remke, C.G. Rolli, T. Hielscher, Y. Cho, M. Kool, P.A. Northcott, M. Jugold, A.V. Bahzin, S.B. Eichmueller, A.E. Kulozik, A. Pscherer, A. Benner, M.D. Taylor S.L. Pomeroy, R. Kemkemer, O. Witt, A. Korshunov, P. Lichter, and S.M. Pfister. MicroRNA-182 promotes metastatic dissemination of non-sonic hedgehog- medulloblastoma.
    Acta Neuropathol., 123:529-38 (2012)
  38. Deibler, J.P. Spatz, R. Kemkemer: Actin fusion proteins alter the dynamics of mechanically induced cytoskeleton rearrangement.
    PLoS One.; 6(8): e22941, (2011)
  39. Uhl, K. Mellert, B. Striegl, M. Deibler, M. Lamla, J.P. Spatz, R. Kemkemer and D. Kaufmann. Cyclic stretch increases splicing noise rate in cultured human fibroblasts.
    BMC Res Notes. 4:470, (2011)
  40. T.Zahn, I.Louban, S.Jungbauer, M.Bissinger, D. Kaufmann, R.Kemkemer (corresponding author), J.P.Spatz: Age-dependent changes in micro-scale stiffness and mechano-responses of cells. SMALL, 7:1480-7 (2011)
  41. Wörtche, M. Deibler, S. Schulz, T. Steinberg, R. Kemkemer (corresponding author), P. Tomakidi. Kinetic fingerprint of two periodontal cell populations subjected to uni-axial cyclic tensile strain.
    Soft Matter, 7, 8612-8618 (2011)
  42. Mellert, M. Uhl, J. Högel, M. Lamla, R. Kemkemer and D. Kaufmann.
    Aberrant single exon skipping is not altered by age in exons of NF1, RABAC1, AATF or PCGF2 in human blood cells and fibroblasts.
    Genes, 2, 562-577; doi:10.3390/genes2030562 (2011)
  43. Kaufmann, Yi Su, S. Biela, S. Jungbauer, J. P. Spatz, R. Kemkemer: Soft lithography detects partial mechano-sensoric blindness to micrometre topography in cultured aged and diseased cells.
    Intern. J. Mat. Res. 102 7, 896-902, (2011)
  44. L. Mills, K. Garikipati, R. Kemkemer: Experimental characterization of tumor spheroids for studies of the energetics of tumor growth. Intern. J. Mat. Res. 102 7, 889-895, (2011)
  45. Ambrosi, G.A. Ateshian, E.M. Arruda, S.C. Cowin, J. Dumais, A. Goriely, G.A. Holzapfel, J.D. Humphrey, R. Kemkemer, E. Kuhl, J.E. Olberding, L.A. Taber, K. Garikipati: Perspectives on biological growth and remodeling.
    Journal of the Mechanics and Physics of Solids 59 863–883, (2011)
  46. G. Kilian, M. Kazda, D. Kaufmann, R. Kemkemer and D. Bartkowiak: Symmetries of the Structure-Bounded Growth Process in Plant-Populations.
    Cell Biochem Biophys 57:87–100, (2010)
  47. H. Narayanan, S.N. Verner, K.L. Mills, Kemkemer and K. Garikipati: In silico estimates of the free energy changes in growing tumor spheroids.
    Journal of Physics: Condensed Matter, 22, 194122, (2010)
  48. Rolli, T. Seufferlein, R. Kemkemer (corresponding author) and J.P. Spatz: Molecular cytoskeleton organization triggers cellular migration behavior inside microfabricated channels.
    PLoS One. 15;5(1):e8726 (2010)
  49. M. Goldyn, C.Ballestrem, P. Kaiser, J.P. Spatz, R. Kemkemer: The kinetics of force-induced cell reorganization depends on microtubules and actin.
    Cytoskeleton, 67:241–250 (2010)
  50. Ahmed, T. Wolfram, A. Goldyn, K. Bruellhoff, B. Aragüés Rioja, M. Möller, J.P. Spatz, T. A. Saif, J. Groll, R. Kemkemer: Myoblast morphology and organization on biochemically micro-patterned hydrogel coatings under cyclic mechanical strain.
    Biomaterials, 31 250–258, (2010)
  51. M. Goldyn, B. Aragüés Rioja, J.P. Spatz, C. Ballestrem and R. Kemkemer: Force-Induced Cell Polarisation is Linked to RhoA-Driven, Microtubule-Independent Focal Adhesion Sliding, Journal of Cell Science 122, 3644-3651, (2009)
  52. Biela, S. Yi, J.P. Spatz, R. Kemkemer: Different sensitivity of EC and SMC to topography in the nano-micro range.
    Acta Biomaterialia 5, 2460–2466, (2009)
  53. Huang J, Gräter SV, Corbellini F, Rinck S, Bock E, Kemkemer R, Kessler H, Ding J, Spatz J P: Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion.
    Nano Letters 9, 1111-1116, (2009)
  54. Jungbauer, H. Gao, J.P. Spatz, R. Kemkemer: Two Characteristic Regimes in Frequency Dependent Dynamic Reorientation of Fibroblasts on Cyclically Stretched Substrates
    Biophysical Journal. 95: 3470-3478, (2008)
  55. G. Kilian, D. Bartkowiak, D. Kaufmann, R. Kemkemer: The general growth logistics of cell populations.
    Cell Biochem Biophys 51: 51-66 (2008)
  56. P. Girard, El.A. Cavalcanti-Adam, R. Kemkemer and J.P. Spatz: Cellular chemomechanics at interfaces: sensing, integration and response.
    Soft Matter, (3),307-326 (2007)
  57. Kemkemer, S. Jungbauer, D. Kaufmann, H. Gruler. Cell Orientation by a Microgrooved Substrate Can Be Predicted by Automatic Control Theory.
    Biophysical Journal. 90: 4701-4711 (2006)