M. Sc. Simon Heine

Contact

Building 2, room 008

Tel: 07121 271-1496

Mail: simon.heine@dont-want-spam.reutlingen-university.de 

Research Projects

CV

 

Since 06/2014:PhD student at the Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart and University of Tübingen

“Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options”

 

09/2011 – 11/2014: Pharmaceutical Biotechnology (M. Sc.), University of Applied Sciences Jena

Master thesis: “Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options” at the Institute of Cell Biology and Immunology of the University of Stuttgart

 

03/2008 – 08/2011: Pharmaceutical Biotechnology (B. Sc.), University of Applied Sciences Biberach

Bachelor thesis: “Establishing a production process on the basis of HEK293 suspension cells” at U3 Pharma GmbH München

Thematic Priorities

  • Co-culture systems
  • Cell-based test systems
  • Organ-on-a-chip
  • GC-MS analysis

Publications

Heine, Simon; Kleih, Markus; Giménez, Neus; Böpple, Kathrin; Ott, German; Colomer, Dolors et al. (2018): Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA. In: Journal of hematology & oncology 11 (1), S. 112. DOI: 10.1186/s13045-018-0657-6.

Höring, Elisabeth; Montraveta, Arnau; Heine, Simon; Kleih, Markus; Schaaf, Lea; Vöhringer, Matthias C. et al. (2017): Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma. In: British journal of haematology 177 (4), S. 557–561. DOI: 10.1111/bjh.14571.

Schaaf, Lea; Schwab, Matthias; Ulmer, Christoph; Heine, Simon; Mürdter, Thomas E.; Schmid, Jens O. et al. (2016): Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. In: Cancer research 76 (10), S. 2868–2875. DOI: 10.1158/0008-5472.CAN-15-2908.