Development of tumor-on-chip system for studying invasion on cancer cells

The aim of this project is the development of a 3D organ-on-a-chip for the application of electric fields to tumor spheroids in hydrogel systems. The system will allow long-term studies (up to weeks) on 3D tumor spheroids and the influence of electric fields on growth (volume development and shape) as established 3D-in-vitro model.
Further, the set-up will be used for studying the tumor spheroid growth depending on electric fields and different hydrogel systems. Experiments will be performed to gain knowledge on the development of tumor spheroids in simple non-adhesive and adhesive hydrogel systems under the influence of electric fields resembling endogenous fields (in vivo situation) to decipher the influence of electric fields on tumor development.

Project funded by HAW-Prom program (Ing. Benjamin Naggay).