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Prof. Dr. Petra Kluger


Building 2, room 2-118

Tel: 07121 271-2061


  • Human Biology
  • Fundamentals of Biomedicine
  • Tissue Engineering
  • Immunology
  • Biofabrication and Regenerative Medicine
Thematic Priorities
  • Tissue Engineering
  • Cell material interactions
  • Biomaterials and surface modification
  • Cell-based in vitro assays

01/2019 – 12/2028 Association at the faculty of Natural Sciences at the University of Hohenheim, Germany with the right to award doctorates (Dr. rer. nat.)

Since 09/2018 Vice-president at Reutlingen University, Germany

Since 11/2017 Full Professor (W3) for Tissue Engineering and Biofabrication at Reutlingen University, Germany

11/2013 – 10/2017 Shared-Professor (W3) for Tissue Engineering (49%) at Reutlingen University, Germany

05/2013 – 10/2017 Head of the Department Cell and Tissue Engineering (51%) at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany

05/2009 – 04/2012 Deputy Head of the Department Cell and Tissue Engineering and group leader at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany

Education and Training

08/2016 – 09/2016 DAAD Short-term lectureship (Stipend) for teaching Biofabrication at Worcester Polytechnic Institute in Massachusetts, USA

10/2010 – 10/2011 Baden-Württemberg Certificate for University Didactic 150 h advanced training in various aspects of didactic

07/2009 Doctoral Examination passed with “summa cum laude” at the University of Stuttgart, Germany

05/2006 – 04/2009 PhD-stipend from the Peter and Traudl Engelhorn foundation  

11/2007 – 11/2008 Postgraduate distance study on Nanobiotechnology at the University of Kaiserslautern

10/2000 – 04/2006 Studies of Technical Biology at the University of Stuttgar

Studies aboard                        

10/04 – 12/04 student research project in Dahab, Egypt 

07/03 – 08/03 polar biological expedition to Greenland

Selected Awards

11/2014 Winner of the Freudenberg Idea Trophy for “Smart Medical surfaces”

11/2012 Award ring (“Ehrenring”) of the Association of German Engineers

05/2009 Posterward at the 3rd International Symposium “Interface Biology of Implants” in Rostock, Germany

05/2006 3 year PhD-stipend from the Engelhorn foundation


Keller, S., Liedek, A., Shendi, D., Bach, M., Tovar, GEM., Kluger, PJ., Southan, A. (2020) Eclectic characterisation of chemically modified cell-derived matrices obtained by metabolic glycoengineering and re-assessment of commonly used methods. RSC Adv., 2020,10, 35273-35286

Schmidt FF, Nowakowski S and Kluger PJ (2020) Improvement of a Three-Layered in vitro Skin Model for Topical Application of Irritating Substances. Front. Bioeng. Biotechnol. 8:388. doi: 10.3389/fbioe.2020.00388

Keller, S., Wörgötter, K., Liedek, A., Kluger, PJ., Bach, M., Tovar, GEM., Southan, A. Azide-Functional Extracellular Matrix Coatings as a Bioactive Platform for Bioconjugation. ACS Appl Mater Interfaces. 2020;12(24):26868-26879. doi:10.1021/acsami.0c04579

Nellinger, S, Schmidt, I, Heine, S, Volz, A‐C, Kluger, PJ. Adipose stem cell‐derived extracellular matrix represents a promising biomaterial by inducing spontaneous formation of prevascular‐like structures by mvECs. Biotechnology and Bioengineering. 2020; 1– 13.

Keller, S, Bakker, T, Kimmel, B, Rebers, L., Götz, T., Tovar, GEM, Kluger, PJ., Southan, A. Azido‐functionalized gelatin via direct conversion of lysine amino groups by diazo transfer as a building block for biofunctional hydrogels. J Biomed Mater Res. 2020; 1– 15.

Leucht, A., Volz, A., Rogal, J., Borchers, K., Kluger, PJ. Advanced gelatin-based vascularization bioinks for extrusion-based bioprinting of vascularized bone equivalents. Sci Rep 10, 5330 (2020).

Nellinger, S., Keller, S., Southan, A., et al., Kluger, P.J. (2019). Generation of an azide-modified extracellular matrix by adipose-derived stem cells using metabolic glycoengineering. Current Directions in Biomedical Engineering, 5(1), pp. 393-395. Retrieved 25 Nov. 2019,

Ann-Cathrin Volz, Birgit Omengo, Sandra Gehrke, Petra J.Kluger. Comparing the use of differentiated adipose-derived stem cells and mature adipocytes to model adipose tissue in vitro. Differentiation, Volume 110, 2019, Pages 19-28, ISSN 0301-4681,

Kleinhans, C, Schmohl, L, Barz, J, Kluger, PJ. Low‐pressure plasma activation enables enhanced adipose‐derived stem cell adhesion. J Biomed Mater Res. 2019; 1– 9.

A. Wenz, I. Tjoeng, I. Schneider, P. J. Kluger, K. Borchers: Improved vasculogenesis and bone matrix formation through coculture of endothelial cells and stem cells in tissue-specific methacryloyl gelatin-based hydrogels; Biotechnol Bioeng. 10/2018; DOI:10.1002/bit.26792

A.-C. Volz, L. Hack, P. J. Kluger: A Cellulose-based material for vascularized adipose tissue engineering; J Biomed Mater Res B. 09/2018; DOI:10.1002/jbm.b.34235

B. Huber, E. Hoch, I. Calderon, K. Borchers, P. J. Kluger: A versatile perfusion bioreactor and endothelializable photo cross-linked tubes of gelatin methacryloyl as promising tools in tissue engineering; Biomedizinische Technik. Biomedical engineering. 08/2018; DOI:10.1515/bmt-2018-0015

E. Novosel; K. Borchers; P. J. Kluger; A. Mantalaris; G. Matheis; M. Pistolesi; J. Schneider; A. Wenz; P. I. Lelkes: New Approaches to Respiratory Assist: Bioengineering an Ambulatory Miniaturized Bioartificial Lung; ASAIO J. 06/2018; DOI:10.1097/MAT.0000000000000841

A.-C. Volz, L. Hack, F. B. Atzinger, P. J. Kluger: Completely defined co-culture of adipogenic differentiated ASCs and microvascular endothelial cells; ALTEX 04/2018; DOI:10.14573/altex.1802191

Shkarina, R. Shkarin, V. Weinhardt, E. Melnik, G. Vacun, P.J.  Kluger, K. Loza, M. Epple, S.I. Ivlev, T. Baumbach, M.A. Surmeneva, R.A. Surmenev: 3D biodegradable scaffolds of polycaprolactone with silicate-containing hydroxyapatite microparticles for bone tissue engineering: high-resolution tomography and in vitro study. Sci Rep. 06/2018; DOI: 10.1038/s41598-018-27097-7.

F. V. Schmid, C. Kleinhans, F. F. Schmid,P. J. Kluger: Osteoclast Formation within a Human Co-Culture System on Bone Material as an In Vitro Model for Bone Remodeling Processes; Journal of Functional Morphology and Kinesiology 03/2018; DOI:10.3390/jfmk3010017

A.-C. Volz and P. J. Kluger: Completely serum-free and chemically defined adipocyte development and maintenance; Cytotherapy 02/2018; DOI:10.1016/j.jcyt.2018.01.004

A. Wenz, K. Borchers K, G. E. M. Tovar,P. J. Kluger: Bone matrix production in hydroxyapatite-modified hydrogels suitable for bone bioprinting; Biofabrication 11/2017; DOI:10.1088/1758-5090/aa91ec

A.-C. Volz, B. Huber, A. M. Schwandt, P. J. Kluger: EGF and hydrocortisone as critical factors for the co-culture of adipogenic differentiated ASCs and microvascular endothelial cells; Differentiation 01/2017; DOI:10.1016/j.diff.2017.01.002

S .M. Ruff, S. Keller, D. Wieland, V. Wittmann, G. E. M Tovar, M. Bach, P. J. Kluger: ClickECM: development of a cell-derived extracellular matrix with azide functionalities; Acta biomaterialia 12/2016; DOI:10.1016/j.actbio.2016.12.022

B. Huber, A. Link, K. Linke, S. A. Gehrke, M. Winnefeld, P. J. Kluger: Integration of mature adipocytes to build-up a functional three-layered full-skin equivalent; Tissue Engineering Part C Methods 06/2016; DOI:10.1089/ten.TEC.2016.0141

B. Huber, S. Engelhardt, W. Meyer, H. Krüger, A. Wenz, V. Schönhaar, G. E. M. Tovar, P. J. Kluger, K. Borchers: Blood-Vessel Mimicking Structures by Stereolithographic Fabrication of Small Porous Tubes Using Cytocompatible Polyacrylate Elastomers; Biofunctionalization and Endothelialization 04/2016; 7(2). DOI:10.3390/jfb7020011

A.-C. Volz, B. Huber, P. J. Kluger: Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering; Differentiation 03/2016; DOI:10.1016/j.diff.2016.02.003

B. Huber, A. M. Czaja, P. J. Kluger: Influence of epidermal growth factor (EGF) and hydrocortisone on the co-culture of mature adipocytes and endothelial cells for vascularized adipose tissue engineering; Cell Biology International 02/2016; 40(5); DOI:10.1002/cbin.10595

A- Wenz, K. Janke, E. Hoch, G. E. M. Tovar, K. Borchers, P. J. Kluger: Hydroxyapatitemodified gelatin bioinks for bone bioprinting; BioNanoMaterials 01/2016; DOI:10.1515/bnm-2015-00187 

B. Huber, A.-C. Volz, P. J. Kluger: Understanding the cross-talk of mature adipocytes and endothelial cells in physiological fatty tissue for vascularized adipose tissue engineering; Cell and Tissue Res 08/2015; DOI:10.1007/s00441-015-2274-9

M. A. Surmeneva, C. Kleinhans, G. Vacun, P. J. Kluger, V. Schönhaar, M. Müller, S. B. Hein, A. Wittmar, M. Ulbricht, O. Prymak, C. Oehr, R. A. Surmenev: Nano-hydroxyapatitecoated metal-ceramic composite of iron-tricalcium phosphate: Improving the surface wettability, adhesion and proliferation of mesenchymal stem cells in vitro; Colloids Surf B Biointerfaces 11/2015; 135: 386–393; DOI:10.1016/j.colsurfb.2015.07.057

B. Huber and P. J. Kluger: Decelerating mature adipocyte dedifferentiation by media composition; Tissue Engineering Part C Methods 09/2015; DOI:10.1089/ten.TEC.2015.0166

B. Huber, A.-C. Volz, P. J. Kluger: How do culture media influence in vitro perivascular cell behavior?; Cell Biology International 07/2015; DOI:10.1002/cbin.10515

B. Huber, K. Borchers, G. E. M. Tovar, P. J. Kluger: Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering; Journal of Biomaterials Applications 05/2015; DOI:10.1177/0885328215587450

C. Kleinhans, R. R. Mohan, G. Vacun, T. Schwarz, B. Haller, Y. Sun, A. Kahlig, P. J. Kluger, A. Finne-Wistrand, H. Walles, J. Hansmann: A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects; Biotechnology Journal 05/2015; DOI:10.1002/biot.201400813

C. Kleinhans, G. Vacun, R. Surmenev, M. Surmeneva, P. J. Kluger: Testing the in vitro performance of hydroxyapatite coated magnesium (AZ91D) and titanium concerning cell adhesion and osteogenic differentiation; 01/2015. DOI:10.1515/bnm-2015-0002

C. Kleinhans, F. F. Schmid, F. V. Schmid, P. J. Kluger: Comparison of osteoclastogenesis and resorption activity of human osteoclasts on tissue culture polystyrene and on natural extracellular bone matrix in 2D and 3D; Journal of Biotechnology 01/2015; 205: 101–110 205. DOI:10.1016/j.jbiotec.2014.11.039

A. Southan, M. Mateescu, V. Hagel, M. Bach, C. Schuh, C. Kleinhans, P. J. Kluger, S. Tussetschläger, I. Nuss, T. Haraszti, S. V. Wegner, J. P. Spatz, H. Boehm, S. Laschat, G. E. M. Tovar: Toward Controlling the Formation, Degradation Behavior, and Properties of Hydrogels Synthesized by Aza‐Michael Reactions; Macromolecular Chemistry and Physics 08/2013; 214(16):1865–1873. DOI:10.1002/macp.201300359

V. Hagel, M. Mateescu, A. Southan, S. V. Wegner, I. Nuss, T. Haraszti, C. Kleinhans, C. Schuh, J. P. Spatz, P. J. Kluger, M. Bach, S. Tussetschläger, G. E. M. Tovar, S. Laschat, H. Boehm: Desmosine-Inspired Cross-Linkers for Hyaluronan Hydrogels; Scientific Reports 06/2013; 3:2043. DOI:10.1038/srep020438

C. Kleinhans, J. Barz, S. Wurster, M. Willig, C. Oehr, M. Müller, H. Walles, T. Hirth, P. J. Kluger: Ammonia plasma treatment of polystyrene surfaces enhances proliferation of primary human mesenchymal stem cells and human endothelial cells; Biotechnology journal 8/2013, No.3, pp.327-337. DOI:10.1002/biot.201200210

M. Schleicher, J. Hansmann, B. Elkin, P. J. Kluger, S. Liebscher, A. J. T. Huber, O. Fritze, C. Schille, M. Müller, K. Schenke-Layland,M. Seifert, H. Walles, H.-P. Wendel, U. A. Stock: Oligonucleotide and parylene surface coating of polystyrene and ePTFE for improved endothelial cell attachment and hemocompatibility; International journal of biomaterials. Online journal (2012), Art. 397813, 14 S. DOI:10.1155/2012/397813 

E. C. Novosel, W. Meyer, N. Klechowitz, H. Krüger, M. Wegener. G. E. M Tovar, H. Walles, T. Hirth, P. J. Kluger: Evaluation of Cell-Material Interactions on Newly Designed, Printable Polymers for Tissue Engineering Applications, Advanced Engineering Materials Vol. 13, Issue 12, S. B467–B475. DOI:10.1002/adem.201180018

E. C. Novosell, C. Kleinhans C, P. J. Kluger: Vascularization is the Key Challenge in Tissue Engineering; Advanced drug delivery reviews, Vol. 63, Issue .4-5, S.300-311. DOI:10.1016/j.addr.2011.03.004

M. Votteler, P. J. Kluger, H. Walles, K. Schenke-Layland: Stem Cell Microenvironments - Unveiling the Secret of How Stem Cell Fate is Defined, Macromol Biosci.; Vol. 10; S.1 302-15. DOI:10.1002/mabi.201000102

P. J. Kluger, R. Wyrwa, J. Weisser, J. Maierle, M. Votteler, C. Rode, M. Schnabelrauch, H. Walles H, K. Schenke-Layland: Electrospun Non-Woven Matrix of Poly(D/L-lactide-co-L-lactide) – A Suitable Scaffold Material for Soft Tissue Engineering; J Mater Sci Mater Med.; Vol. 21; S. 2665-71. DOI: 10.1007/s10856-010-4128-z