Prof. Dr. Petra Kluger


Building 2, room 2-118

Tel: 07121 271-2061



  • Human Biology
  • Fundamentals of Biomedicine
  • Tissue Engineering
  • Immunology
  • Biofabrication and Regenerative Medicine

Thematic Priorities

  • Tissue Engineering
  • Cell material interactions
  • Biomaterials and surface modification
  • Cell-based in vitro assays


A.-C. Volz, L. Hack, P. J. Kluger: A Cellulose-based material for vascularized adipose tissue engineering; J Biomed Mater Res B.; submitted

A.-C. Volz, L. Hack, F. B. Atzinger, P. J. Kluger: Completely defined co-culture of adipogenic differentiated ASCs and microvascular endothelial cells; ALTEX 04/2018; DOI:10.14573/altex.1802191

F. V. Schmid, C. Kleinhans, F. F. Schmid, P. J. Kluger: Osteoclast Formation within a Human Co-Culture System on Bone Material as an In Vitro Model for Bone Remodeling Processes; Journal of Functional Morphology and Kinesiology 03/2018; DOI:10.3390/jfmk3010017

A.-C. Volz and P. J. Kluger: Completely serum-free and chemically defined adipocyte development and maintenance; Cytotherapy 02/2018; DOI:10.1016/j.jcyt.2018.01.004

A. Wenz, K. Borchers K, G. E. M. Tovar, P. J. Kluger: Bone matrix production in hydroxyapatite-modified hydrogels suitable for bone bioprinting; Biofabrication 11/2017; DOI:10.1088/1758-5090/aa91ec

A.-C. Volz, B. Huber, A. M. Schwandt, P. J. Kluger: EGF and hydrocortisone as critical factors for the co-culture of adipogenic differentiated ASCs and microvascular endothelial cells; Differentiation 01/2017; DOI:10.1016/j.diff.2017.01.002

S .M. Ruff, S. Keller, D. Wieland, V. Wittmann, G. E. M Tovar, M. Bach, P. J. Kluger: ClickECM: development of a cell-derived extracellular matrix with azide functionalities; Acta biomaterialia 12/2016; DOI:10.1016/j.actbio.2016.12.022

B. Huber, A. Link, K. Linke, S. A. Gehrke, M. Winnefeld, P. J. Kluger: Integration of mature adipocytes to build-up a functional three-layered full-skin equivalent; Tissue Engineering Part C Methods 06/2016; DOI:10.1089/ten.TEC.2016.0141

B. Huber, S. Engelhardt, W. Meyer, H. Krüger, A. Wenz, V. Schönhaar, G. E. M. Tovar, P. J. Kluger, K. Borchers: Blood-Vessel Mimicking Structures by Stereolithographic Fabrication of Small Porous Tubes Using Cytocompatible Polyacrylate Elastomers; Biofunctionalization and Endothelialization 04/2016; 7(2). DOI:10.3390/jfb7020011

A.-C. Volz, B. Huber, P. J. Kluger: Adipose-derived stem cell differentiation as a basic tool for vascularized adipose tissue engineering; Differentiation 03/2016; DOI:10.1016/j.diff.2016.02.003

B. Huber, A. M. Czaja, P. J. Kluger: Influence of epidermal growth factor (EGF) and hydrocortisone on the co-culture of mature adipocytes and endothelial cells for vascularized adipose tissue engineering; Cell Biology International 02/2016; 40(5); DOI:10.1002/cbin.10595

A- Wenz, K. Janke, E. Hoch, G. E. M. Tovar, K. Borchers, P. J. Kluger: Hydroxyapatitemodified gelatin bioinks for bone bioprinting; BioNanoMaterials 01/2016; DOI:10.1515/bnm-2015-00187 

B. Huber, A.-C. Volz, P. J. Kluger: Understanding the cross-talk of mature adipocytes and endothelial cells in physiological fatty tissue for vascularized adipose tissue engineering; Cell and Tissue Res 08/2015; DOI:10.1007/s00441-015-2274-9

M. A. Surmeneva, C. Kleinhans, G. Vacun, P. J. Kluger, V. Schönhaar, M. Müller, S. B. Hein, A. Wittmar, M. Ulbricht, O. Prymak, C. Oehr, R. A. Surmenev: Nano-hydroxyapatitecoated metal-ceramic composite of iron-tricalcium phosphate: Improving the surface wettability, adhesion and proliferation of mesenchymal stem cells in vitro; Colloids Surf B Biointerfaces 11/2015; 135: 386–393; DOI:10.1016/j.colsurfb.2015.07.057

B. Huber and P. J. Kluger: Decelerating mature adipocyte dedifferentiation by media composition; Tissue Engineering Part C Methods 09/2015; DOI:10.1089/ten.TEC.2015.0166

B. Huber, A.-C. Volz, P. J. Kluger: How do culture media influence in vitro perivascular cell behavior?; Cell Biology International 07/2015; DOI:10.1002/cbin.10515

B. Huber, K. Borchers, G. E. M. Tovar, P. J. Kluger: Methacrylated gelatin and mature adipocytes are promising components for adipose tissue engineering; Journal of Biomaterials Applications 05/2015; DOI:10.1177/0885328215587450

C. Kleinhans, R. R. Mohan, G. Vacun, T. Schwarz, B. Haller, Y. Sun, A. Kahlig, P. J. Kluger, A. Finne-Wistrand, H. Walles, J. Hansmann: A perfusion bioreactor system efficiently generates cell-loaded bone substitute materials for addressing critical size bone defects; Biotechnology Journal 05/2015; DOI:10.1002/biot.201400813

C. Kleinhans, G. Vacun, R. Surmenev, M. Surmeneva, P. J. Kluger: Testing the in vitro performance of hydroxyapatite coated magnesium (AZ91D) and titanium concerning cell adhesion and osteogenic differentiation; 01/2015. DOI:10.1515/bnm-2015-0002

C. Kleinhans, F. F. Schmid, F. V. Schmid, P. J. Kluger: Comparison of osteoclastogenesis and resorption activity of human osteoclasts on tissue culture polystyrene and on natural extracellular bone matrix in 2D and 3D; Journal of Biotechnology 01/2015; 205: 101–110 205. DOI:10.1016/j.jbiotec.2014.11.039

A. Southan, M. Mateescu, V. Hagel, M. Bach, C. Schuh, C. Kleinhans, P. J. Kluger, S. Tussetschläger, I. Nuss, T. Haraszti, S. V. Wegner, J. P. Spatz, H. Boehm, S. Laschat, G. E. M. Tovar: Toward Controlling the Formation, Degradation Behavior, and Properties of Hydrogels Synthesized by AzaMichael Reactions; Macromolecular Chemistry and Physics 08/2013; 214(16):1865–1873. DOI:10.1002/macp.201300359

V. Hagel, M. Mateescu, A. Southan, S. V. Wegner, I. Nuss, T. Haraszti, C. Kleinhans, C. Schuh, J. P. Spatz, P. J. Kluger, M. Bach, S. Tussetschläger, G. E. M. Tovar, S. Laschat, H. Boehm: Desmosine-Inspired Cross-Linkers for Hyaluronan Hydrogels; Scientific Reports 06/2013; 3:2043. DOI:10.1038/srep020438

C. Kleinhans, J. Barz, S. Wurster, M. Willig, C. Oehr, M. Müller, H. Walles, T. Hirth, P. J. Kluger: Ammonia plasma treatment of polystyrene surfaces enhances proliferation of primary human mesenchymal stem cells and human endothelial cells; Biotechnology journal 8/2013, No.3, pp.327-337. DOI:10.1002/biot.201200210

Schleicher, M.; Hansmann, J.; Elkin, B.; Kluger, P. J.; Liebscher, S.; Huber, A. J. T.; Fritze, O.; Schille, C.; Müller, M.; Schenke-Layland, K.; Seifert, M.; Walles, H.; Wendel, H.-P.; Stock, U. A.: Oligonucleotide and parylene surface coating of polystyrene and ePTFE for improved endothelial cell attachment and hemocompatibility; International journal of biomaterials. Online journal (2012), Art. 397813, 14 S. DOI:10.1155/2012/397813 

Novosel E. C., Meyer W., Klechowitz N., Krüger H., Wegener M., Tovar G. E. M., Walles H., Hirth T., Kluger P. J.: Evaluation of Cell-Material Interactions on Newly Designed, Printable Polymers for Tissue Engineering Applications, Advanced Engineering Materials Vol. 13, Issue 12, S. B467–B475. DOI:10.1002/adem.201180018

Novosel E. C., Kleinhans C., Kluger P. J.: Vascularization is the Key Challenge in Tissue Engineering; Advanced drug delivery reviews, Vol. 63, Issue .4-5, S.300-311. DOI:10.1016/j.addr.2011.03.004

Votteler M., Kluger P. J., Walles H., Schenke-Layland K.: Stem Cell Microenvironments - Unveiling the Secret of How Stem Cell Fate is Defined, Macromol Biosci.; Vol. 10; S.1 302-15. DOI:10.1002/mabi.201000102

Kluger P. J., Wyrwa R., Weisser J., Maierle J. Votteler M., Rode C., Schnabelrauch M. Walles H., Schenke-Layland K.: Electrospun Non-Woven Matrix of Poly(D/L-lactide-co-L-lactide) – A Suitable Scaffold Material for Soft Tissue Engineering; J Mater Sci Mater Med.; Vol. 21; S. 2665-71. DOI: 10.1007/s10856-010-4128-z