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Publication Experimental Cell Research

Age-dependent migratory behavior of human endothelial cells revealed by substrate microtopography

Cell migration is part of many important in vivo biological processes and is influenced by chemical and physical
factors such as substrate topography. Although the migratory behavior of different cell types on structured
substrates has already been investigated, up to date it is largely unknown if specimen's age affects cell migration
on structures. In this work, we investigated age-dependent migratory behavior of human endothelial cells from
young (≤ 31 years old) and old (≥ 60 years old) donors on poly(dimethylsiloxane) microstructured substrates
consisting of well-defined parallel grooves.